Altogether, the presence of KCC2 mutations in epilepsy coupled with preclinical proof-of-principle for KCC2 as a therapeutic target motivates a rich stream of future studies to further investigate the mechanistic roles of KCC2 in epileptogenesis and how manipulation of KCC2 activity can be leveraged pharmacologically for therapeutic benefit in epilepsy syndromes and conditions of hyperexcitation. The gene discussed is SLC12A5; the disease is epilepsy syndrome.