For example, α-asarone, a chemical component found in various plants (e.g., Annonaceae and Araceae species), was shown to significantly suppress M1 polarization and to attenuate the production of pro-inflammatory cytokines by inhibiting the NF-κB signaling, and to eventually mitigate PD-like behavioral anomalies in the MPTP-induced mouse model (Kim et al., 2015). Here, NFKB1 is linked to Parkinson disease.