DYRK1A and Dravet syndrome: Previous studies have investigated proteomic changes in mouse models of DS (Fernandez et al., 2009; Wang et al., 2009; Ahmed et al., 2012; Ishihara et al., 2014; Nguyen et al., 2018; Vacano et al., 2018) and fetal samples from DS individuals (Bajo et al., 2002; Weitzdoerfer et al., 2002; Shin et al., 2006; Cho et al., 2013; Liu et al., 2016) but this is the first comparing the brain proteomic changes upon pro-cognitive treatments (green tea extract and EE), in Dyrk1A transgenic mice.