Although EphA4 expression levels decrease in adult life, EphA4 is considered as a major contributor in neurological disorders such as spinal cord injury, stroke, and Alzheimer’s disease (Goldshmit et al., 2011; Lemmens et al., 2013; Munro et al., 2013; Fu et al., 2014; Vargas et al., 2014). This evidence concerns the gene EPHA4 and early-onset autosomal dominant Alzheimer disease.