It was reported that NEAT1 facilitated 5‐FU resistance of breast cancer via miR‐211/HMGA2 axis.24 In addition, NEAT1 increased 5‐FU chemoresistance of renal cell carcinoma through miR‐34a/c‐Met axis.25 These results indicated that NEAT1 might regulate chemoresistance of CRC via multiple ways. Here, HMGA2 is linked to hereditary clear cell renal cell carcinoma.