It has been previously reported that a variety of G‐protein coupled‐receptor proteins promote metastasis by affecting the EMT process of cancer cells,21, 22, 23, 24, 25, 26 including in lung cancer.27, 28, 29 However, more studies are warranted to further explore the molecular mechanism of OPN3 in affecting the EMT of LUAD. This evidence concerns the gene OPN3 and lung cancer.