With TCGA data analysis, we found that the expression of OPN3 in LUAD and other cancers (breast cancer, cervical cancer, colon adenocarcinoma, ovarian serous cystadenocarcinoma, pancreatic adenocarcinoma, rectal adenocarcinoma, skin cutaneous melanoma, uterine corpus endometrial carcinoma, uterine carcinosarcoma, Fig 1a,b, P < 0.05) was higher than in the corresponding normal tissues. This evidence concerns the gene OPN3 and ovarian serous cystadenocarcinoma.