PPARG and Mental deterioration: For example, Makaryus reported that sevoflurane has neurotoxic effects on the development of brain.9 Decreased connectivity between excitatory neurons in the prefrontal cortex has been shown to be correlated with cognitive impairments induced by sevoflurane.10 Homoplastically, sevoflurane facilitates cognitive decline by aggravating microglia‐regulated neuroinflammation in a rat model via down‐regulating PPAR‐γ activity in the hippocampus.1 Once the surgical method is determined, the degree of trauma and inflammatory response cannot be changed.