Inhibition of the CXCR4-CXCL12 axis, on the other hand, can sensitize cancer cells to chemotherapy or radiotherapy by inhibiting the interaction between the CXCR4-expressing tumor cells and stromal cells, resulting in decreased cancer cell protection by the CXCL12 releasing stromal cells [19–21]. Here, CXCL12 is linked to neoplasm.