TERT/telomerase contributes to multicancer hallmarks, and it not only confers malignant cells an immortal phenotype via telomere stabilization, but also promotes proliferation/survival, stemness, invasion, and drug resistance of cancer cells via telomere lengthening-independent mechanisms, thereby driving tumor progression including metastatic growth [26, 41–45]. The gene discussed is TERT; the disease is neoplasm.