Inhibition of BCL-XL results in thrombocytopenia due to platelets being dependent on BCL-XL for survival50, whereas inhibition of MCL-1 will affect survival of neutrophils51, thus mandating the establishment of a therapeutic index and optimal scheduling for the drug combination, as has been achieved to manage Navitoclax-induced thrombocytopenia in patients52. Here, MCL1 is linked to Thrombocytopenia.