Apart from these metabolism processes, S-nitrosylated proteins in PDAC tissues and PANC-1 cells were significantly enriched in multiple biological processes associated with cancer initiation, development and metastasis, including the renal cell carcinoma, actin cytoskeleton regulation, pancreatic cancer, neurotrophin signaling, leukocyte trans-endothelial migration, focal adhesion, adherent junctions, and cell cycle pathways (Figs. 5b, c; Supplemental Fig. S4–S9). Here, BDNF is linked to pancreatic neoplasm.