In addition, IL-6/IL-8-specific neutralizing antibody and selective JAK2/STAT3 inhibitor treated GC-MSC-primed macrophages were also studied and their promoting effects on the migration and invasion abilities of gastric cancer cells were partly blocked, suggesting the key roles of IL-6 and IL-8 in macrophage polarization regulated by GC-MSCs. This evidence concerns the gene CXCL8 and gastric cancer.