In patients without enthesitis at baseline, secukinumab 300 and 150 mg again showed higher responses than placebo for ACR20 (48.8% and 60.4% vs 13.8%), ACR50 (32.6% and 32.9% vs 4.1%), and PASI 90 (56.4% and 48.9% vs 10.8%), with reduced disease activity (DAS28-CRP − 1.3 and − 1.5 vs − 0.4) and improved physical function and HRQoL (HAQ-DI − 0.4 and − 0.5 vs − 0.2; SF-36 PCS 6.1 and 7.0 vs 2.0) (Table 2). This evidence concerns the gene CRP and enthesitis.