At week 16, patients with enthesitis at baseline treated with secukinumab 300 and 150 mg showed better outcomes compared with placebo for ACR20 (51.6% and 44.3% vs 19.5%, respectively), ACR50 (31.4% and 21.0% vs 7.5%), PASI 90 (66.5% and 51.8% vs 13.1%), DAS28-CRP (− 1.4 and − 1.0 vs − 0.5), HAQ-DI (− 0.5 and − 0.3 vs − 0.2), and SF-36 PCS (6.1 and 3.5 vs 2.3). This evidence concerns the gene CRP and enthesitis.