IL17A and enthesitis: In another head-to-head trial of an IL-17 inhibitor (ixekizumab) versus adalimumab (SPIRIT-P1), ixekizumab showed higher resolution of enthesitis (as measured by LEI) than adalimumab at week 24 (ixekizumab 80 mg once every 4 weeks, 43%, and ixekizumab 80 mg once every 2 weeks, 39%, vs adalimumab, 33%) [37].