Only two rare single-nucleotide polymorphisms (SNPs) at the ANKRD26 gene, the rs139049098 (minor allele frequency, MAF: C = 0.0004/2) and the rs191015656 (MAF: A = 0.0004/2), have been so far associated with severe obesity in humans [19]. The gene discussed is ANKRD26; the disease is obesity due to melanocortin 4 receptor deficiency.