EGFR and lung adenocarcinoma: In the current study, we screened and verified that shisa3, as a suppressor, prevents EGFR-TKI resistance and suppresses the CSC phenotype in lung adenocarcinoma as follows: (1) Lung adenocarcinoma patients with high expression of shisa3 had a better response to EGFR-TKIs, indicating that shisa3 may be used to predict the efficacy of TKI therapy.