Notably, while both BRCA1 mRNA and proteins levels were consistently down regulated in most cell types, including motor neurons derived from ALS patient with FUS P525L mutation and ALS patient spinal cord tissues with FUS pathology, redcued BRCA1 protein levels was not consistent with mRNA level in the patient fibroblasts, likely due to unexplored regulation at the protein level, which needs further investigation. The gene discussed is BRCA1; the disease is amyotrophic lateral sclerosis.