ERBB2 and breast cancer: Inhere we evaluated trend of changes in BC clinicopathology during a 22-year period in Iran and found that a significant change regarding age of first presentation, tumor size, stage, grade, grade of nucleus, tumor necrosis, ER, PR and HER2 status, invasion status, type of axillary management, rate of chemotherapy, rate of lymph node involvement, type of operation, and pattern of recurrence was seen among patients with BC during the study period (p < 0.05).