On the other hand, Wnt antagonist sFRP1 and sFRP2 act as negative modulators of the disintegrin and metalloproteinase domain 10 protein (ADAM10) [90], which is an α-secretase responsible for shedding of the TREM2 ectodomain to produce soluble TREM2 (sTREM2) [86]; and recent studies indicate that sTREM2 displays a protective role in AD brain [91–93]. The gene discussed is TREM2; the disease is Alzheimer disease.