The mean baseline GDF15 values were 491 pg/ml (95% CI 429–553) in healthy controls, 546 pg/ml (95% CI 478–614) in those with MS, 560 pg/ml (95% CI 502–617) in those with mild/moderate ME/CFS and 602 pg/ml (95% CI 531–674) in severely affected ME/CFS patients. This evidence concerns the gene GDF15 and myalgic encephalomeyelitis/chronic fatigue syndrome.