Twenty (20.41%) had PID: 13 Common Variable Immune Deficiency (CVID), three IgG-2 subclass deficiency, one dyskeratosis congenita, one hyper IgE syndrome (STAT3 dominant negative loss of function deficiency) and one patient with interferon-γ receptor and interleukin-12 deficiency, one patient each. This evidence concerns the gene STAT3 and common variable immunodeficiency.