INS and obesity due to melanocortin 4 receptor deficiency: Furthermore, insulin resistance was mainly defined by insulin [model 2: loading = 0.66, p < 0.001; model 3: loading = 0.72, p < 0.001], and obesity by BMI [model 2: loading = 0.85, p < 0.001; model 3: loading = 0.83, p < 0.001].