In both the OSA with and without EDS groups, MetS was mainly represented by insulin resistance [model 2: loading = 0.93, p < 0.001; model 3: loading = 0.88, p < 0.001] and obesity [model 2: loading = 0.91, p < 0.001; model 3: loading = 0.89, p < 0.001]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.