Besides, pathways such as epithelial-mesenchymal-transition (EMT), angiogenesis, hypoxia, myogenesis and cholesterol homeostasis etc. were found to more significantly enriched in EGFR-MUT LGGs, indicating the different patterns of histopathology, tumor microenvironment (TME) and metabolism process in EGFR mutant positive and negative LGGs. The gene discussed is EGFR; the disease is neoplasm.