APOE and early-onset autosomal dominant Alzheimer disease: Of the genes highlighted by expression quantitative trait loci analysis (though in a tissue of unclear relevance), APOE (chromosome 19) has been widely studied in cardiovascular (and other, notably Alzheimer) diseases,52 whereas the function of MCPH1-AS1(CTD-2541M15.3;chromosome 8) is thought to be as a regulator of MCPH1, a DNA damage response gene with no obvious role in vessel wall biology.