It is worth noting that genetic correlations between coronary artery disease (ie, cardiovascular end points) and fasting insulin or glucose are quite strong but not reported due to their unimpressive P values (rg 0.23 [se 0.11], P=0.041 and 0.14 [0.09] P=0.095 respectively).63 Rheumatoid arthritis demonstrates weak and nonsignificant associations with coronary artery disease (−0.06 [0.08], P=0.438), but a moderate and nominally significant association with IMTmax. Here, INS is linked to coronary artery disorder.