In another malignant carcinoma cell line, HCT-116 cells, we identified a similar pattern of changes in relative dhCer content and increased concentration of S1P, compared to Cer content; however, increase in GSL synthesis, which has just recently been reported in colon tumor samples [55], was not found in the HCT-116 cell line. This evidence concerns the gene MBTPS1 and colonic neoplasm.