It has been reported that folate stress (induced by the expression of a major folate metabolism enzyme, ALDH1L1, or by folate depletion) leads to CERS6-dependent increase of Cer levels in human colon carcinoma HCT-116 cells [23], and that CERS6 could also be a target of anti-folate chemotherapeutic drug methotrexate [24]. This evidence concerns the gene CERS6 and colon carcinoma.