SGPL1 and colonic neoplasm: S1P can be also dephosphorylated by S1P phosphatases (SGPP1,2) and phospholipid phosphatases (PLPP1-3), or it can be irreversibly degraded by S1P lyase (SGPL1), which is highly expressed in enterocytes, and which has been found to be downregulated in colon cancer [37].