Based on logistic regression in this study, we reported that there is significant between SNP (rs17466684) of Epoxide Hydrolase 2 gene (EPHX2) with depression symptoms (AOR = 7.854, 95% CI = 1.330–46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579–37.197). The gene discussed is EPHX2; the disease is major depressive disorder.