GBA1 and Gaucher disease: Clinical observations showed that in Gaucher disease, congenital disorders of sphingolipid metabolism [4] and damaged GBA1 enzyme activity [13] promoted the occurrence of malignant disease, in particular of MGUS, MM, and B-cell lymphomas, that are more frequent than in the healthy population [12], especially commonly described in GD1 (the most frequent Gaucher disease type I) [14,15].