Moreover, regarding cancer chemoresistance, miR-320a is a mediator of the chemoresistance of BC cells by targeting TRPC5 and NFATc3 and the expression of miR320a is regulated by methylation of its promoter and the transcription factor, v-ets erythroblastosis virus E26 oncogene homolog 1 [117]. The gene discussed is TRPC5; the disease is cancer.