ABCB1 and breast cancer: Previously it has been reported that TRPC5 mediated Ca2+entry, stimulating the ATP-binding cassette, subfamily B, member 1 (ABCB1) pump overproduction in drug-resistant BC cells, and suppressing TRPC5, reversing drug resistance through the TRPC5-NFATc3-Ca2+-ABCB1 pathways [25].