TRPA1 and melanoma: Experiments using mouse dorsal root ganglion neurons and human TRPA1-transfected HEK293 (hTRPA1-HEK293) cells as well as naïve mice and TRPA1-knockout mice (1 mg/Kg/day) and B16-F10 melanoma cells treated with DBZ, demonstrated that DBZ directly activates TRPA1 and sensitizes it indirectly by generating oxidative stress products.