In the same view, treatment of MCF-7 BC cells with cisplatin and/or alpha-lipoic acid (ALA) by activating TRPV1 increases [Ca2+]i levels, ROS production, lipid peroxidation, mitochondrial membrane depolarization, PARP-1, caspase activation, and apoptosis, and these effects are decreased by CPZ [73]. The gene discussed is TRPV1; the disease is breast cancer.