EGFR and p53 mutations did not show a significant association with the survival parameters in our cohort, in fact it was the opposite, they even seem to reverse the normal prognostic meaning that we usually associate, our series is complete, but not so large to consider a single variation of these parameter related to OS, we suppose that some different types of analysis and molecular factors have to be considered in the future and in the next classifications, EGFR and p53 are actually useful, but not sufficient, to understand the behavior of a GBM at the time of diagnosis. Here, EGFR is linked to glioblastoma.