PTEN and liver cancer: As reviewed recently, miR-221, whose expression raises approximately 70%–80% in liver cancer [6], could affect several cancer related pathways by modulating multiple gene targets, including the pro-apoptotic protein B-cell lymphoma 2-modifying factor (BMF) [7], the inhibitor of the phosphoinositide 3-kinase pathway phosphatase and tensin homolog (PTEN) [8], ect.