The fact that GSK3B is implicated in many inflammatory events, and considering that IL-6 levels in blood are negatively correlated with miR-1185-1, indicates that these miRNAs could have a key role in the progression of obesity-induced inflammation, and that this gene could be an important target in the battle against obesity related complications. The gene discussed is GSK3B; the disease is obesity due to melanocortin 4 receptor deficiency.