The A375, the HT-144 and the M74 human melanoma cell lines express the mutated form V600E of BRAF, in the A375 and in the M74 cells the promoter of the telomerase reverse transcriptase (TERT) is mutated and in M74 cells the expression of p53 is very low, furthermore in the HT-144 cells also the Ataxia Telangiectasia Mutated (ATM) protein is mutated [32,33,34]. This evidence concerns the gene TP53 and melanoma.