In conclusion, these results collectively showed that the treatment with nanomolar concentrations of (Bu2Sn)2TPPS and (Bu3Sn)4TPPS induces in melanoma cells, although with different quantitative effects, the decreased expression of integrin and CAM adhesion receptors and in HT-144 cells treated with (Bu3Sn)4TPPS, the decreased expression and activation of FAK, thus suggesting that these complexes could inhibit the migration and metastatic dissemination of melanoma cells using different mechanisms. The gene discussed is PTK2; the disease is melanoma.