Therefore, the high DNA binding affinity of these organotin(IV) compounds and mostly of (Bu3Sn)4TPPS, elicits the alteration of the DNA conformation [15] and the induction of DNA damage suggested by the increased expression of the full-length PARP-1 as well as by the inhibition of the growth and by the blockage of the cell cycle that we showed in treated melanoma cells. This evidence concerns the gene PARP1 and melanoma.