We first validated the importance of different anti-apoptotic BCL-2 family protein expression in our representative DLBCL cell line panel with different genetic backgrounds (5 GCB and 3 ABC) and correlated anti-apoptotic protein expression to their functional anti-apoptotic dependency as determined by BH3 profiling (Figure 1, Figures S1 and S2). The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.