The existing literature documents that neurotoxic stimuli, such as ischemia [21, 23], glutamate [26], β-amyloid [27, 28], or 1-methyl-4-phenylpyridinium (MPP+) [29, 30], can induce p65 activation and the transcription of a panel of pro-apoptotic genes in neurons. The gene discussed is RELA; the disease is ischemia.