Although recent scRNA-seq studies had shed light on the Treg component of CD4+ TILs (Ahmadzadeh et al., 2019; Azizi et al., 2018; Zhang et al., 2018; Zheng et al., 2017a), our study assessed the transcriptomes of both regulatory and conventional components, in the tumor itself, and in draining lymphoid organs. This evidence concerns the gene CD4 and neoplasm.