B8R-specific TRM CD8+ T cells in skin challenged with control peptide remained mostly CD69+/CD103+, whereas the expanded B8R-specific TRM population became largely CD69+/CD103− (Figures 2F and 2H), which we have recently shown to be the dominant TRM CD8+ T cell population that forms following secondary VACV skin infection (Osborn et al., 2019). Here, CD8A is linked to skin infection.