We found that about 25% of the MDD effect on obesity (BMI) was mediated by the CRP level, but no evidence of mediation was found with others adiposity measures or IL-6; Atypical MDD ‒ one distinct subtype of MDD that is characterized by reversed neurovegetative symptoms (i.e. increased appetite, leaden paralysis, and hypersomnia) ‒ has been frequently associated with high levels of inflammatory markers26 as well as obesity27 , differently than melancholic MDD. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.