As presented in Supplementary Table S2, univariate logistic regression showed that multifocal disease (P=0.002), bilobar tumor location (P=0.011), largest nodule size >3.3 cm (P<0.001), portal vein invasion (P<0.001), higher ECOG performance status (P<0.001), higher BCLC stage (P=<0.001), abnormal ALP (P=0.025), and abnormal AFP (P=0.001) were factors for predicting worse CR. The gene discussed is AFP; the disease is neoplasm.