To analyze the predictive value of baseline characteristics for PFS, univariate and multivariate Cox's regression analyses were performed, showing that multifocal disease (P<0.001), bilobar tumor location (P=0.001), largest nodule size >3.3 cm (P=0.002), portal vein invasion (P<0.001), hepatic vein invasion (P<0.001), higher ECOG performance status (P<0.001), higher BCLC stage (P<0.001), combination of ordinary embolization agent (P=0.024), and abnormal AFP (P=0.001) were negatively associated with PFS (Supplementary Table S4). This evidence concerns the gene AFP and neoplasm.