KLF4 and obesity due to melanocortin 4 receptor deficiency: Cardiac KLF4 controlled mitochondrial homeostasis and functional changes.24 Macrophage KLF4 determined the plasticity of adipose tissue resident macrophages and systemic inflammation in obese mice.13 More importantly, studies also found KLF4 functioned as a suppressor of renal fibrogenesis.15, 16 Endothelial KLF4 exhibited protection against ischaemic acute kidney injury.18 Interestingly, current study also found the crucial role of KLF4 in obesity‐related renal injuries.