Macrophage infiltration is one important character of obesity‐related nephropathy.20, 21 As showed in Figure 3E‐3F, HFD obviously initiated F4/80+ macrophage infiltration into kidneys (P < .001), but overexpression of Klf4 decreased the macrophage accumulation (P < .01). The gene discussed is KLF4; the disease is obesity due to melanocortin 4 receptor deficiency.