NFKB1 and metabolic disease: NF‐κB signalling, as a crucial transcriptional factor in regulating inflammatory response, is widely studied in metabolic diseases.20, 21 As showed in Figure 2F‐2G, PA obviously increased the phosphorylated levels of IκB and IκB degradation, whereas overexpression of Klf4 decreased the activation of NF‐κB (P < .01).