Guo et al showed that PGC1α attenuated obesity‐induced rat renal mesangial hypertrophy.6 Podocyte PGC1α protein levels in human biopsy samples were decreased in patients with diabetic kidney disease.27 Besides, the improved activities of AMPK and SIRT protected mitochondrial function and renal biology.7, 8 As co‐factor for mitochondrial functional, KLF4 promoted mitochondrial biogenesis in heart through cooperating with PGC1α/PPARγ pathway,24 but the role of KLF4 on renal mitochondrial function is unknown. The gene discussed is PPARGC1A; the disease is obesity due to melanocortin 4 receptor deficiency.