NF‐κB signalling, as a crucial transcriptional factor in regulating inflammatory response, is widely studied in metabolic diseases.20, 21 As showed in Figure 2F‐2G, PA obviously increased the phosphorylated levels of IκB and IκB degradation, whereas overexpression of Klf4 decreased the activation of NF‐κB (P < .01). Here, NFKB1 is linked to Other metabolic disease.