CNMD and Parkinson disease: The CnMd‐Pf complex has been implicated in PD pathophysiology and suggested as a possible target for functional neurosurgery.49, 50 Neuropathological analyses have shown that neuron loss in CnMd‐Pf is present in nonsymptomatic MPTP macaques and early PD stages and progresses thereafter.10, 11 The present findings indicate that dopamine denervation is also present in CnMd‐Pf and that it occurs in the symptomatic parkinsonian stage.