Indeed, OC development is related to germline BRCA1/BRCA2 mutations, nulliparity, lifetime ovulation cycles and endometriosis,1, 2, 6 while no data have thus far suggested a link with viral infection, even though viral signatures can be found in clinical OC samples.47 Thus, if RIG‐I becomes activated in ovarian tumors in the absence of virus, the question arises who is providing the ligand (i.e., 5′‐triphosphate RNA)? The gene discussed is BRCA2; the disease is endometriosis.