In this single‐center, retrospective, explorative biomarker study of 141 cases with epithelial OC, we uncovered the prognostic significance of the innate immune receptor helicase RIG‐I, whose canonical function in physiology is to elicit an antiviral response after pattern‐based recognition of viral RNA.7, 8 Upregulated in the malignant ovary, RIG‐I associated with certain clinicopathological characteristics such as tumor grade, while showing virtual independence from others including histological subtype and postoperative tumor burden. Here, RIGI is linked to neoplasm.