RIGI and melanoma: Ligand‐mediated activation of RIG‐I signaling triggers apoptotic programs in melanoma cells13 and confers protective antitumor immunity mediated at least in part by natural killer cells, dendritic cells and interferons.14 In OC cells, targeted activation of RIG‐I leads to MHC class I upregulation and the secretion of proinflammatory mediators, such as IL‐6, CCL5 and TNF‐α.15 By this mechanism, OC cells are induced to undergo apoptosis and subsequently become phagocytosed by cocultured monocytes.