Recently, therapeutic strategies to TIME of breast cancer including efforts to (1) expand CD8+ T cells, NK cells, and DCs, (2) improve antigen presentation and (3) decrease inhibitory cytokines, TAMs, regulatory T cells and myeloid derived suppressor cells (MDSCs) had shed light on altering the TIME to make breast tumors more sensitive to immunotherapy [35]. This evidence concerns the gene CD8A and breast cancer.