In addition, most TIME-related immunosuppressive molecules, including HIF1A, FAP, IL10, TGFB1, and multiple checkpoint inhibitors positively correlated with the CD204 expression levels in all subtypes; however, IL6, CD276, VTCN1, and IDO1 displayed different correlation values in different subtypes, providing potential evidence for different combination strategies of breast cancer immunotherapy in the four molecular subtypes. The gene discussed is HIF1A; the disease is breast cancer.