In addition, most TIME-related immunosuppressive molecules, including HIF1A, FAP, IL10, TGFB1, and multiple checkpoint inhibitors positively correlated with the CD204 expression levels in all subtypes; however, IL6, CD276, VTCN1, and IDO1 displayed different correlation values in different subtypes, providing potential evidence for different combination strategies of breast cancer immunotherapy in the four molecular subtypes. Here, HIF1A is linked to breast carcinoma.