In this study about c‐MET in the context of NSCLC and tobacco smoke, it was shown that chronic exposure to cigarette smoke extract or tobacco smoke‐derived carcinogen benzo[α]pyrene, B[α]P, but not nicotine‐derived nitrosamine ketone (NNK), diminished treatment response to EGFR‐TKIs in wild‐type EGFR‐expressing NSCLC cells. This evidence concerns the gene EGFR and non-small cell lung carcinoma.