RPL10 and acute lymphoblastic leukemia: Although none of these variants have been shown to drive stabilization of TP53, the RPS23 p.Arg67Lys variant linked to dysmorphism and the RPL10 p.Arg98Ser variant linked to T-ALL are reported to alter the translational fidelity of ribosomes by increasing frameshifting and the readthrough of stop codons (28,36).