In addition, key enzymes in maintaining DNA methylation balance, such as DNA methyltransferase 3A (DNMT3A) (17) and Ten-Eleven-Translocation 2 (TET2), are frequently mutated in myeloid leukaemia (18,19), reinforcing the importance of DNA methylation in myeloid differentiation. This evidence concerns the gene TET2 and myeloid leukemia.