Our data show elevated mTOR signaling in mutp53;ErbB2 vs. wtp53;ErbB2 human cancer cells as indicated by high levels of downstream effectors of mTOR—p70S6 and pS6, whereas the level of mTOR and p-mTOR protein were comparable (Fig. 5b and Supplementary Figs. 4b and 5b). The gene discussed is ERBB2; the disease is cancer.