Furthermore, a single dose of γ-irradiation at the time of pre-malignant lesions onset (5 Gy to 80-day-old mice) significantly shortened both tumor latency and overall survival by approximately 80 days, in both p53−/+;ErbB2 and p53H/+;ErbB2 genotypes (Fig. 2a), but not in p53+/+;ErbB2 mice (Fig. 2b). This evidence concerns the gene TP53 and neoplasm.