As we have previously observed that the MBD2 and/or p66α down-regulation in cancer cell lines resulted in the depressed EMT and conversely promoted epithelial differentiation, we reasoned that disrupted PPI between MBD2 and p66α by the ABA and APC compounds could result in suppression of metastatic potentials of cancer cells by regulating the Mi-2/NuRD CRC–mediated EMT. The gene discussed is APC; the disease is colorectal carcinoma.