The integrated Mi-2/NuRD CRC includes one CHD (either CHD3 or CHD4), one HDAC (HDAC1 or HDAC2), two DOC1, three MTA (MTA1, MTA2, and MTA3), six RbAp46/48, two p66 (p66α or p66β), and one MBD (MBD2 or MBD3) molecules (17, 18), where the molecular interaction of MBD2 with p66α critically mediates the proper assembly of CRC (17, 19). The gene discussed is CHD4; the disease is colorectal carcinoma.