MAVS and systemic lupus erythematosus: The association between IL-10 and HLA-G5 secretion by MSCs notwithstanding, BM-MSCs from SLE patients have a proinflammatory and senescence-associated phenotype mediated by a mitochondrial antiviral signaling protein (MAVS) that induces an IFN-β feedback loop (Gao et al., 2017).