In the malignancies mentioned above the balance between TEAD-VGLL4 and TEAD-YAP complexes is disrupted (Jiao et al., 2014; Zhang et al., 2014, 2017), thus VGLL4 is regarded as a tumor suppressor by negatively regulating the Hippo pathway to inhibit cell proliferation. This evidence concerns the gene VGLL4 and neoplasm.