CD146 has emerged as a biomarker for angiogenesis (Zheng et al., 2009; Wang and Yan, 2013; Nomikou et al., 2015), and it has been identified as an attractive target for imaging and therapy in HCC (Thomann et al., 2014; Hernandez et al., 2016). This evidence concerns the gene MCAM and hepatocellular carcinoma.