VEGFA and retinopathy of prematurity: It is, in fact, easy to understand that the administration of propranolol, a molecule able to reduce the production of VEGF, may be useful during the proliferative phase of ROP, when VEGF is dramatically increased, and a reduction of VEGF is desirable, but detrimental if administered during the ischemic phase, when levels of VEGF are too low to permit a normal vascularization of the retina, and an increase of VEGF is suitable.